I've done this twice with the 22RE, and a third time will commence shortly. On my motorhome, it allowed me to take mountain passes in second gear when before it took third. Thrilled with exhaust swap results.
Stock downpipe to 2" Magnaflow 94104 cat. Flange from old cat removed with reciprocating saw and welded to front of new cat to enable use of stock bracket and donut gasket.
Rear cat secured to 2" stainless mid pipe with TorcTite stainless lap clamps from Verocious Motorsports ebay store. Mid pipe came from JC Whitney in 6' length. FexEx lost the first one when I was in a wrenching panic before a road trip, and they promptly sent me another one overnight at no charge. Yowza! About a month later, the lost one landed on my porch. Double yowza!
Mid pipe to 2.25" Raptor 50051FLT muffler using another TorcTite 2" clamp and a 2" to 2.25" adapter welded to muffler intake. Exit muffler to 2.25" stainless flex hose from JC Whitney, used another TorcTite clamp. Cat and muff astonishingly cheap from ebay seller.
Made exhaust tip out short piece of 2.25 from AutoBone. Assortment of hangers from AutoBone, OReilly, and Pep Boys. Each had distinctly different types of hangers. 4Runner had lots of empty threaded stuff underneath to enable creative hanging.
Especially on the motorhome, I've beat this setup to death for years on testicle-shattering washboard roads and logging trails that some normal people would hesitate to tackle with a 4x4 ("Are you REALLY gonna drive up there??"). Held together like a champ so far, and I can take the whole banana apart in two shakes with a ratchet and 2 sockets. Total cost was a couple hundred bucks and change.
Sounded so good that I decided it was a must to replace that fruity-sounding horn on such an outwardly macho ride.
Muffler and cat ebay seller
LinkyI offered about $7 less than his BIN price and they took it and delivered very fast.
High falootin' exhaust clamps
LinkyFlex tubing for muffler out to tailpipe
LinkyGood luck with your project.