Welcome. I did the Weber swap last November and have been trying to get it set up right ever since. It's a great carb but some guys like the Mikuni for extreme off-road angles. I swapped mine for the Weber 32/36 DGEV (electric choke) from Redline Weber
http://www.redlineweber.com. The stock Mikuni is the same size (32/36) but uses vacuum to open the secondary barrel, the Weber is mechanical. I adapted the stock air cleaner to the Weber because of the extreme cold weather here so I could take advantage of the heated duct from the exhaust. I now have a large box full of vacuum lines and other crap from the swap.
You won't pass emissions testing with the Weber...if your state requires it.
Mine is running great and I'm glad I did it. I can help you with any questions if you decide to do it. Here's a thumbnail of what I ended up doing:
I replaced the primary idle jet size from #60 to #70.
I replaced the secondary idle jet from #50 to #65.
I put a fuel pressure regulator (1-5.5 psi) in-line into the fuel line from the pump that used to go to the accelerator pump on the stock carb then connected the line to the fuel return line to the tank. I set the regulator to 1-1/2 psi to approximate the restriction in the stock carb. I'm still fiddling with it, but I'm pretty close right now.
Please add details (the more the better) about your truck in "My Home" signature section so it appears with each of your posts so we don't have to ask (or remember) what you have.
I've talked with good mechanics with 20 plus years of experience that refuse to work on the Mikuni carbs...that should give you a clue. The stock carbs are good when they're set up and running right but can be a huge headache when not.