Love 33x1050s and have run them on 3 out of my last four rigs. Bear in mind though, that even though they are lighter than the standard 33x1250, they're still a big diameter increase from 30s. This will affect braking and especially gearing. If you have an auto this will have a bigger effect on the road, since the shift points will be affected by the change in rpm. If a 5 speed, be prepared to slip that clutch a little more on start up, and you'll be dropping out of 5th sooner on hills, obviously. 4 Low gets used a lot more offroad, and crawling slowly (not that you can really do that now) becomes even more difficult.

These are all trade offs, and for my money they're worth it for the extra clearance, but definitely something to keep in mind.