Doug-
It's not really an exit.. 421 intersects with I-40 in Winston-Salem at around the Jonestown Road exit (sorry, don't know the number). Right after that (like .5 miles) I-40 and Business 40 split, you want I-40. Then like 4 exits later, you'll get off at 109 (Thomasville). Go straight through the light and it leads you onto 109 and into Thomasville.

That is the way we go most often and is usually the fastest... Let me know if you need more detail..

HTH <img src="/forums/images/graemlins/kewl.gif" alt="" />

Jessica

edit: Smiley is kinda right, what looks like 421 on that map crossing over Business 40 (the top of the oval) is more commonly referred to here at I-40..