Sure. Plumb it and run it. You may or may not need to mess with the computer management, depending on how you set it up.

From this point, it all up to you how much you want to do and how much you are willing to spend. There are lots of electronic goodies that you can use to manage fuel and timing. There is machining you can do help if you go big PSI.

But...at this point; RESEARCH. Read read read. There is lots written on the topic, just not specific to Isuzus.

Michael