If you're safe and sane with the gas pedal as it is, the learning curve with a locker is easy and should not present any big concerns. You'll get some tire scrub in tight turns and parking lots. On the rare occasions when you get slick weather down there, you'll want to be careful of side slip from punching the gas, as well as when you get a lot of water on the road, but other than that....pretty strightforward imho.

Detroit historically has a better reputation than the Powertrax products, but also the T100/Tacoma/Tundra offering from Detroit is newer to the market than the NoSlip for these differentials. I had a NoSlip for a couple of years and enjoyed it before I upgraded to ARBs. I would definitely stick with a LSD or ARB up front, and there, adding any traction unit up front can be lethal to the ifs if you're not careful with the gas in situations where you might suddenly catch traction, especially on oversized tires. That said, simply making sure the wiring between the seat and brain is in order can prevent a lot of problems and net you years of benefit from either unit.

edit- Erik beat me to the click. Lots of good points. <img src="/forums/images/graemlins/cheers.gif" alt="" />