The more you stick the tire out the more trouble you will have in clearing them, although you dont want them to rub the frame while turning either so you might need them out a bit more. It is hard to say, I dont have mine on yet so I cant offer too much in depth advice. What I do know is that I was able to stuff 33x10.5 TSL Thornbirds on 15x7 wheels with 3.5 BS with a 2" body lift and 2" leveling spacers in the front. I cant say that all this totally applies to you though. Hopefully some others can offer some advice as well. What kind of lifts were you looking into? Why is it so time sensitive? It is important to do it right the first time to avoid burned money down the road or issues with your truck.