You can put the HDD and CD on the same cable, but depending on what you're doing, you may see performance issues.

I found a thread on the internet which talks about USB issues on that board and affects on the secondary controller they tend to have:

http://www.techsupportforum.com/hardware-support/motherboards-bios-cpu/5629-usb-5-6-don-t-work.html

HTH

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Stay the Trail!