Yeah if its about 10-20 miles you dont have to unhook the rear d-shaft.
If youre towing it on a road trip, DEFINTATELY do it and tie it up to the frame, you'd be retarded not to.

89 4Runner
3" BL, M/T locks, 33"bfg mt, bilstein, Kayline, tubebumper, toyotafiberglass panels
TBI: Elocker,3.4 w/ORS,b+b,S2Sstg2cams,arias pistons,P+P intake,TRDs/c,URDpullies+7th,downey headers,MAPECU2,WEGO WB, SupraMAF,walboro255,stg4clutch, EPaOo2 sim