If its an automatic, no. If its a 5 speed you "could" but I wouldnt do it for very far. Most vehicles that can be towed on all 4 behind an RV have a neutral on the transfer case (if 4wd). Isuzus dont. Only good way to do it is remove the drive shaft or have a drive shaft disconnect installed.

--Dave

1999 Rodeo LS 3.2 4x4 5 Speed
32x11.50-15 BFG T/A KO on US Wheel 94 series
3" Lift - Rancho 9000x
Rear No-Slip Locker
Flowmaster 50 series SUV 2.25"

There is a very fine line between "hobby" and "mental illness." - Dave Barry