Update:
Now it's running fine for the most part (out of nowhere), but the AFR gauge is showing that the mixture is still jumping around a lot. Definitely not as stable as usual.

Could a bad front O2 sensor be the culprit?

'99 Tacoma Xtra cab V6 TRD
TRD Supercharged, URD 7th injector and 2.2" pulley, 32X11.5 BFG All-Terrains, OME 881 3-inch lift/Toytec AAL, 5100 Series Bilsteins all around, and ProComp 130 lights.
No I'm not some creepy naked guy...